A Radiofluorinated Nanobody PET Tracer to Dynamically Visualize Differential Nectin4 Expression In Vivo

) of 6.77 nM in cell lines. The tracer enabled clear visualization of nectin4-expressing lesions, and its uptake profile and pharmacokinetic behavior were characterized using dynamic PET imaging and kinetic analysis. A correlation between PET signal intensity and histological nectin4 expression was also observed in tumor models. Thus, it may have the potential to become a nectin4 tracer for clinical applications.