亲爱的研友该休息了!由于当前在线用户较少,发布求助请尽量完整地填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!身体可是革命的本钱,早点休息,好梦!

Frequency and Diagnostic Implications of Paramagnetic Rim Lesions in People Presenting for Diagnosis to a Multiple Sclerosis Clinic

多发性硬化 医学 放射科 精神科
作者
Brian Renner,Elizabeth Verter,Martina Absinta,Lynn Daboul,Praneeta Raza,Melissa L. Martin,Quy Cao,Carly M. O’Donnell,Paulo Rodrigues,Marc Ramos,Vesna Prchkovska,J. Andrew Derbyshire,Christina Azevedo,Amit Bar‐Or,Eduardo Caverzasi,Peter A. Calabresi,Bruce Cree,Léorah Freeman,Roland G. Henry,Erin E. Longbrake
出处
期刊:Neurology [Lippincott Williams & Wilkins]
卷期号:105 (6) 被引量:1
标识
DOI:10.1212/wnl.0000000000213912
摘要

Paramagnetic rim lesions (PRLs) are a well-established imaging biomarker of chronic active multiple sclerosis (MS) lesions. PRLs have been shown to be highly specific for MS (∼90% specificity), and their prevalence has been estimated to be approximately 50% in patients with clinically established diagnoses of MS. In this study, we evaluated the frequency and diagnostic value of PRLs in patients at first clinical presentation. Adults age 18-64 years presenting with clinical symptoms or radiologic suspicion of demyelinating disease referred to academic specialty MS centers without a definitive diagnosis were prospectively enrolled in a multicenter, cross-sectional, observational study. Phase images from high-resolution 3D echo-planar imaging were acquired on 3-tesla brain MRI and evaluated for PRLs by 3 independent raters, blinded to diagnosis, with adjudication from a fourth expert rater. Diagnostic performance of PRLs for a diagnosis of MS using the 2017 McDonald criteria as gold standard was evaluated using diagnostic thresholds based on the presence of at least 1 PRL (≥1 PRL) or at least 2 PRLs (≥2 PRLs). Seventy-eight participants were analyzed (mean age, years [range]: 45.0 [18-64] female sex n = 55 [71%]); a total of 124 PRLs were counted in 36 (46%) of the 78 participants (median: 3 PRLs; range: 1-9 PRLs). Thirty-two (89%) of the 36 PRL-positive participants fulfilled 2017 McDonald criteria, and the remaining 4 (11%) had an alternate diagnosis. The presence of ≥1 PRL had a sensitivity of 0.86 (95% CI 0.71-0.95) and a specificity of 0.90 (95% CI 0.77-0.97). For ≥2 PRLs, specificity increased to 0.95 (95% CI 0.83-0.99), whereas sensitivity decreased to 0.59 (95% CI 0.42-0.75). For participants with MS, shorter duration from initial symptom onset was associated with higher probability of having PRLs, with the odds of being PRL positive (≥1 PRL) increasing by 28% for every 1 year decrease from symptom onset (odds ratio 1.28 per year, 95% CI 1.03-1.59, p = 0.03). PRLs are highly prevalent early in patients with MS at the time of first clinical presentation and can differentiate MS from mimics with high accuracy.

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
馆长应助科研通管家采纳,获得10
11秒前
GPTea应助科研通管家采纳,获得20
11秒前
馆长应助科研通管家采纳,获得10
11秒前
打打应助科研通管家采纳,获得30
11秒前
GPTea应助科研通管家采纳,获得20
11秒前
1分钟前
量子星尘发布了新的文献求助10
1分钟前
学术垃圾12138完成签到,获得积分10
1分钟前
馆长应助科研通管家采纳,获得10
2分钟前
Ava应助科研通管家采纳,获得10
2分钟前
fsznc1完成签到 ,获得积分0
2分钟前
阿言完成签到 ,获得积分10
3分钟前
yoona发布了新的文献求助10
4分钟前
yoona完成签到,获得积分10
5分钟前
5分钟前
简单成危完成签到,获得积分20
6分钟前
6分钟前
简单成危发布了新的文献求助30
6分钟前
NexusExplorer应助Paperharvester采纳,获得10
7分钟前
年鱼精完成签到 ,获得积分10
8分钟前
朱志伟完成签到,获得积分10
8分钟前
馆长应助科研通管家采纳,获得30
8分钟前
8分钟前
sci2025opt完成签到 ,获得积分10
8分钟前
8分钟前
量子星尘发布了新的文献求助10
8分钟前
8分钟前
wzgkeyantong发布了新的文献求助10
8分钟前
wzgkeyantong完成签到,获得积分10
9分钟前
lina完成签到 ,获得积分10
9分钟前
Paperharvester完成签到,获得积分10
9分钟前
传奇3应助zm采纳,获得10
10分钟前
白华苍松发布了新的文献求助20
11分钟前
思源应助白华苍松采纳,获得10
11分钟前
chuhong完成签到 ,获得积分10
11分钟前
Honsarn完成签到,获得积分10
12分钟前
12分钟前
YifanWang应助科研通管家采纳,获得30
12分钟前
YifanWang应助科研通管家采纳,获得30
12分钟前
YifanWang应助科研通管家采纳,获得30
12分钟前
高分求助中
(应助此贴封号)【重要!!请各用户(尤其是新用户)详细阅读】【科研通的精品贴汇总】 10000
Zur lokalen Geoidbestimmung aus terrestrischen Messungen vertikaler Schweregradienten 1000
Schifanoia : notizie dell'istituto di studi rinascimentali di Ferrara : 66/67, 1/2, 2024 1000
Circulating tumor DNA from blood and cerebrospinal fluid in DLBCL: simultaneous evaluation of mutations, IG rearrangement, and IG clonality 500
Food Microbiology - An Introduction (5th Edition) 500
Laboratory Animal Technician TRAINING MANUAL WORKBOOK 2012 edtion 400
Progress and Regression 400
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 内科学 生物化学 物理 计算机科学 纳米技术 遗传学 基因 复合材料 化学工程 物理化学 病理 催化作用 免疫学 量子力学
热门帖子
关注 科研通微信公众号,转发送积分 4851734
求助须知:如何正确求助?哪些是违规求助? 4150288
关于积分的说明 12856796
捐赠科研通 3898351
什么是DOI,文献DOI怎么找? 2142435
邀请新用户注册赠送积分活动 1162189
关于科研通互助平台的介绍 1062380