Mechanisms of food-derived active peptides ameliorating or preventing hyperlipidemia and bioinformatics analysis of molecular targets

Hyperlipidemia is a prevalent metabolic disorder that can lead to other illnesses. Natural products in food, such as active peptides, can help alleviate hyperlipidemia. This study seeks to elucidate the mechanism through which food-derived active peptides (FDAPs) mitigate hyperlipidemia. Through comprehensive literature analysis, we estimated the efficacy and mechanism of FDAPs in reducing blood lipid levels. The results indicate that the structure-activity relationship (SAP) of FDAPs, the ability to regulate intestinal flora, and the regulation of relevant gene expression serve as the primary mechanisms. We leverage bioinformatics methods to analyze the lipid-lowering mechanism of FDAPs. By utilizing the OMIM database, GeneCard database, and TTD database, we identified the differential expressed genes (DEGs) that intersect with FDAPs, linked to hyperlipidemia. String, GO, and KEGG analysis reveal the further mechanism. Furthermore, we screened out the 22 molecular targets. String, GO, and KEGG analysis revealed that FDAPs likely achieve lipid reduction by regulating the expression of HMGCR, CYP7A1, and FAS. The strong correlation between lipid reduction by FDAPs and metabolic pathways, PPAR signaling pathway, and alcoholic liver disease provides valuable insights for the development of novel drugs.