Effect of Interactions Between Endothelial Lipase Gene Polymorphisms and Traditional Cardiovascular Risk Factors on Coronary Heart Disease Susceptibility

The rs2000813CT endothelial lipase genotype is potentially associated with an increased CHD risk in females, whereas the CC genotype may confer a protective effect. Integrating endothelial lipase gene variants with traditional cardiovascular risk factors enhances CHD risk prediction in women. Synergistic interaction between endothelial lipase polymorphisms and environmental factors appears to influence CHD occurrence in this population.