斜发沸石
吸附
化学工程
纳米复合材料
沸石
自愈水凝胶
抗菌活性
化学
材料科学
Zeta电位
壳聚糖
核化学
高分子化学
复合材料
纳米技术
有机化学
纳米颗粒
细菌
生物
工程类
遗传学
催化作用
作者
Mohana Haghbin,Rahime Eshaghi Malekshah,Mahsa Sobhani,Zhila Izadi,Babak Haghshenas,Maryam Ghasemi,Behrooz Sadeghi Kalani,Hadi Samadian
标识
DOI:10.1016/j.ijbiomac.2023.123766
摘要
The main purpose of this study is to synthesize and characterize Persian gum-based hydrogel composited with gentamicin (Gen)-loaded natural zeolite (Clinoptilolite) and to evaluate its biological properties. Clinoptilolite (CLN) was decorated with Gen, and the conjugation was confirmed using computational and experimental assessments. The Monte Carlo adsorption locator module was used to reveal the physicochemical nature of the adsorption processes of Gen on CLN and ALG and gum on Gen@ CLN in Materials Studio 2017 software. Based on the high negative results, the adsorption process was found to be endothermic in all studied cases, and the interaction energies were in the range of physisorption for Gen on CLN and ALG and gum on Gen@CLN. Dynamic light scattering (DLS) and zeta potential analysis showed that the size of pristine CLN was around 2959 nm and the conjugation decreased the size significantly to approximately 932 nm. The hydrogel characterizations showed that the Gen-decorated CLNs are homogenously dispersed into the hydrogel matrix, and the resultant hydrogels have a porous structure with interconnected pores. The release kinetics evaluation showed that around 80 % of Gen was released from the nanocomposite drug during the first 10 h. In vitro studies revealed hemocompatibility and cytocompatibility of the nanocomposite. Microbial assessments indicated dose-dependent antibacterial activity of the hydrogel against gram (+) and gram (-) bacteria. The results showed that the fabricated hydrogel nanocomposite exhibits favorable physicochemical and biological properties.
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