[Regulatory mechanism and potential value of circular RNA in nonalcoholic fatty liver disease progression].

Nonalcoholic fatty liver disease (nonalcoholic fatty liver disease, NAFLD) or metabolic-associated fatty liver disease, has become the most common chronic liver disease worldwide. In recent years, the relationship between NAFLD and non-coding RNA (ncRNA) has attracted the attention of basic and clinical researchers. Circular RNA (circRNA) is a lipid metabolism-related non-coding RNA (ncRNA) that is highly conserved in eukaryotic cells and resembles but differs from linear ncRNAs at their 5'- and 3'-terminal ends. With tissue-specific and steady expression of endogenous ncRNA, miRNA binding sites are contained on closed and circular nucleoside chains, forming the circRNA-miR-mRNA axis or network with proteins, competing with endogenous RNA sponge-like mechanisms, playing a role in inhibiting or promoting the expression of related target genes, and participating in the progression of NAFLD. This paper reviews the circRNA regulatory mechanism, detection technology, and potential clinical value in NAFLD.非酒精性脂肪性肝病（NAFLD）或称代谢相关脂肪性肝病已成为全球最常见慢性肝病。NAFLD与非编码RNA（ncRNA）关系，已引起基础及临床研究的重视。在脂代谢相关ncRNA中，环状RNA（circRNA）在真核细胞中存在高度保守，异同于含5'-末端和3'-末端的线性ncRNAs，具有组织特异性且可稳定表达内源性ncRNA，在封闭、环状核苷链上含miRNA结合位点，形成circRNA-miR-mRNA轴或与蛋白质构成网络，以海绵样机制竞争内源RNA，发挥其抑制或促进相关靶基因表达，参与NAFLD进展。现综述circRNA在NAFLD调控机制、检测技术及其潜在临床价值。.