Unveiling the Threat of Disease X: Preparing for the Next Global Pandemic

ABSTRACT The term “Disease X”, first introduced by the World Health Organization (WHO) in 2018, symbolizes the threat of an unknown pathogen capable of causing a global pandemic. Classified as a “priority pathogens,” Disease X stands alongside well‐known threats like SARS, Ebola, and ZIKV due to its potential for widespread outbreaks. SARS‐CoV‐2 is considered the first “Disease X” to fulfill this prediction, demonstrating the devastating impact such pathogens can have. A future pathogen X could pose an even greater threat, with catastrophic consequences. This paper examines the potential origins of such pathogens, drawing lessons from outbreaks like SARS, MERS, and SARS‐CoV‐2. It also highlights strategic approaches to detect, prevent, and respond effectively to mitigate the risk of future pandemics.