Synthesis and Biological Evaluation of New Chalcone based Thiazole Derivatives: Antimicrobial, Antifungal Activity, ADME and Molecular Docking Studies

The Claisen-Schmidt condensation reaction of 2-acetyl thiophene with heterocyclic carboxaldehyde or substituted benzaldehyde in the presence of alkaline medium was used to synthesize novel thiophene chalcones. Several chalcone heterocycle hybrids appear to have more activity than the standards. These chalcones can be hydroaminated to provide good yields of amino thiazole derivatives. The newly synthesized compounds were characterized with spectroscopic techniques including FT-IR, 1H NMR, 13C NMR and HRMS. In addition to a seed germination inhibition test and an evaluation of the synthesized compounds in vitro antibacterial activity against a variety of bacteria and fungi, the synthesized aminothiazole derivatives underwent molecular docking and in silico ADMET studies.