Discovering Differential Imaging Genetic Modules via Multimodal Fusion-Based Hypergraph Transductive Learning in Alzheimer’s Disease Diagnosis

Brain imaging genetics is a widely focused topic, which has achieved the great successes in the diagnosis of complex brain disorders. In clinical practice, most existing data fusion approaches extract features from homogeneous data, neglecting the heterogeneous structural information among imaging genetic data. In addition, the number of labeled samples is limited due to the cost and time of manually labeling data. To remedy such deficiencies, in this work, we present a multimodal fusion-based hypergraph transductive learning (MFHT) for clinical diagnosis. Specifically, for each modality, we first construct a corresponding similarity graph to reflect the similarity between subjects using the label prior. Then, the multiple graph fusion approach based on theoretical convergence guarantee is designed for learning a unified graph harnessing the structure of entire data. Finally, to fully exploit the rich information of the obtained graph, a hypergraph transductive learning approach is designed to effectively capture the complex structures and high-order relationships in both labeled and unlabeled data to achieve the diagnosis results. The brain imaging genetic data of the Alzheimer's Disease Neuroimaging Initiative (ADNI) datasets are used to experimentally explore our developed method. Related results show that our method is well applied to the analysis of brain imaging genetic data, which accounts for genetics, brain imaging (region of interest (ROI) node features), and brain imaging (connectivity edge features) to boost the understanding of disease mechanism as well as improve clinical diagnosis.