The Future of Personalized Cancer Vaccines

The advent of modern next-generation sequencing and innovative clinical bioinformatics platforms have fueled the development of genomics-guided PCVs targeting neoantigens. As we anticipate the results of several pivotal randomized clinical trials investigating PCVs across solid tumors, collaborative efforts are warranted to apply insights from first-generation trials to leverage the capabilities of PCVs to reduce cancer-associated morbidity and mortality across the spectrum of oncological care.