白质
边缘型人格障碍
部分各向异性
工作记忆
心理学
磁共振弥散成像
扣带回(脑)
联想(心理学)
临床心理学
听力学
医学
神经科学
认知
磁共振成像
心理治疗师
放射科
作者
Xiaoping Yi,Qian Xiao,Yan Fu,Xueying Wang,Lei Shen,Jun Ding,Furong Jiang,Jing Wang,Zhejia Zhang,Bihong T. Chen
标识
DOI:10.1016/j.psychres.2023.115619
摘要
Non-suicidal self-injurious behavior (NSSI) is the core characteristic of adolescent borderline personality disorder (BPD) and visual working memory is involved in the pathological processes of BPD. This study aimed to investigate alterations in white matter microstructure and their association with NSSI and visual working memory in adolescents with BPD.53 adolescents diagnosed with BPD and 39 healthy controls (HCs) were enrolled. White matter microstructure was assessed with the fractional anisotropy (FA) and mean diffusivity (MD) from diffusion tensor imaging (DTI). Correlation analysis was performed to assess the association between FA/MD and core features of BPD. A mediation analysis was performed to test whether the effects of white matter alterations on NSSI could be mediated by visual working memory.Adolescents with BPD showed a reduced FA and an increased MD in the cortical-limbic and cortical-thalamus circuit when compared to the HCs (p < 0.05). Increased MD was positively correlated with NSSI, impulse control and identity disturbance (p < 0.05), and was negatively correlated with the score of visual reproduction. Reserved visual working memory masked the effects of white matter microstructural alterations on NSSI behavior.White matter microstructural deficits in the cortical-limbic and cortical-thalamus circuits may be associated with NSSI and visual working memory in adolescents with BPD. Reserved visual working memory may protect against NSSI.
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