东莨菪碱
医学
天冬氨酸转氨酶
药理学
肝损伤
胆红素
异烟肼
四氯化碳
丙氨酸转氨酶
碱性磷酸酶
组织病理学
白蛋白
汉方
植物化学
内科学
传统医学
化学
生物化学
病理
酶
肺结核
替代医学
有机化学
作者
Swati Sharma,Vishal Sharma,Sunil Taneja,Alka Bhatia,Aishwarya Anand,Amol Patil,Dibyajyoti Banerjee
出处
期刊:Journal of Complementary and Integrative Medicine
[De Gruyter]
日期:2023-09-22
卷期号:20 (4): 797-803
被引量:1
标识
DOI:10.1515/jcim-2023-0168
摘要
The hepatoprotective properties of scopoletin have been explored in carbon tetrachloride (CCl4) induced liver injury but not in drug-induced liver injury (DILI) scenarios. Only N-acetyl-cysteine (NAC) has proven efficacy in DILI treatment. Accordingly, we conducted a study to assess the hepatoprotective action of scopoletin in the anti-tubercular treatment (ATT)-DILI model in Wistar rats, if any.A total of 36 rats were evaluated, with six in each group. A 36-day ATT at 100 mg/kg dose for isoniazid, 300 mg/kg for rifampicin and 700 mg/kg for pyrazinamide were fed to induce hepatotoxicity in rats. Group I and II-VI received normal saline and ATT, respectively. Oral scopoletin (1,5 and 10 mg/kg) and NAC 150 mg/kg were administered in groups III, IV, V and VI, respectively, once daily for the last 15 days of the experiment. LFT monitoring was performed at baseline, days 21, 28, and 36. Rats were sacrificed for the histopathology examination.Aspartate transaminase (AST), alanine transaminase (ALT), alkaline phosphatase (ALP) and bilirubin levels were significantly increased in group II (receiving ATT) compared to normal control on day 28 and day 36 (p<0.05). All three doses of scopoletin and NAC groups led to the resolution of AST, ALT, ALP, and bilirubin changes induced by ATT medications effect beginning by day 28 and persisting on day 36 (p<0.01). An insignificant effect was observed on albumin and total protein levels. The effect was confirmed with antioxidants and histopathology analysis.The study confirms the hepatoprotective efficacy of scopoletin in a more robust commonly encountered liver injury etiology.
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