癌症
肝癌
医学
临床试验
动物模型
疾病
临床前研究
基础研究
动物试验
生物信息学
重症监护医学
病理
医学物理学
内科学
生物
计算机科学
图书馆学
生态学
作者
Luyao Wang,Yongchao Piao,Fei Guo,Wei Jiang,Yurong Chen,Xiangpeng Dai,Xiaoling Zhang
标识
DOI:10.1016/j.biopha.2023.115256
摘要
Preclinical trials play critical roles in assessing the safety and efficiency of novel therapeutic strategies for human diseases including live cancer. However, most therapeutic strategies that were proved to be effective in preclinical cancer models failed in human clinical trials due to the lack of appropriate disease animal models. Therefore, it is of importance and urgent to develop a precise animal model for preclinical cancer research. Liver cancer is one of the most frequently diagnosed cancers with low 5-year survival rate. Recently, porcine attracted increasing attentions as animal model in biomedical research. Porcine liver cancer model may provide a promising platform for biomedical research due to their similarities to human being in body size, anatomical characteristics, physiology and pathophysiology. In this review, we comprehensively summarized and discussed the advantages and disadvantages, rationale, current status and progress of pig models for liver cancer research.
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