氧化应激
胰岛素抵抗
脂肪组织
内分泌学
内科学
抗氧化剂
炎症
肥胖
化学
生物
医学
生物化学
作者
Lauane Gomes Moreno,Nayara Rayane César,Dirceu de Sousa Melo,Maria Thereza Ottoni Figueiró,Edivânia Cordeiro dos Santos,Paulo Henrique Evangelista-Silva,Carina De Sousa Santos,Karine Beatriz Costa,Etel Rocha‐Vieira,Marco Fabrício Dias Peixoto,Cleber Ferraresi,Elizabethe Adriana Esteves
标识
DOI:10.1016/j.mce.2023.112110
摘要
Obesity is associated with low-grade inflammation and oxidative stress, leading to insulin resistance and type II diabetes. Caryocar brasiliense pulp oil (pequi oil – PO) is rich in oleic acid and carotenoids and positively implicated in regulating inflammation and oxidative stress. This study investigated PO's antioxidant and anti-inflammatory effects in a diet-induced obesity model. Male Wistar rats were allocated into three experimental groups: Control (CD), Western Diet (WD), and Western Diet, with 27% of lard switched by PO (WDP). Metabolic, inflammatory, and oxidative stress biomarkers were evaluated after 12 weeks of diet protocols in liver and adipose tissue. WDP rats gained less body mass and epididymal fat, had less hepatic fat infiltration, and were more glucose-tolerant and insulin-sensitive than WD (p < 0.05). In the liver, the WDP group had the highest non-enzymatic antioxidant capacity, SOD and GPx activities, CAT, SOD II, and HSP72 expression compared to WD (p < 0.05). Adipose tissue IL-6 and TNF were reduced, and IL-10 was increased in WDP compared to WD (p < 0.05). Our data suggest that the partial replacement of lard by PO in a Western diet prevented visceral fat accumulation and contributed to reducing inflammation in adipose tissue and liver oxidative stress, improving obesity-related insulin resistance.
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