Development of highly sensitive electrochemical sensor for antipsychotic drug perphenazine using perovskite structured lanthanum cobalt oxide nanoparticles wrapped graphitic carbon nitride nanocomposites

Nowadays, antipsychotics have rather effective in the treatment of psychosis. However, the excess amount of consumption will cause many side effects and harm to human health. Therefore, the rapid and precise evaluation of antipsychotics in real samples is noteworthy for its effective monitoring. Herein, we fabricated a lanthanum cobalt oxide-wrapped graphitic carbon nitride (LaCoO3/g-C3N4) based electrochemical sensor for the detection of perphenazine (PPZ). The structural and morphological analysis of as-prepared materials was scrutinized using various analytical methods. The electrochemical proceedings of LaCoO3/g-C3N4 nanocomposite were investigated by various EIS, CV, and DPV analyses. The nanocomposite exhibit improved active surface area, lower charge transfer resistance, and outstanding electrooxidation than other modified electrodes. Further, the proposed sensor exhibited a broad linear range (0.025–2499.9 μM), excellent sensitivity (1.33 µA µM–1 cm–2), and a low detection limit (LOD) of 0.0043 μM. Moreover, the repeatability, reproducibility, and stability studies with acceptable RSD were observed. Ultimately, this platform was successively validated by sensing the concentration of PPZ in biological fluids with a recovery of > 96.6%. Hence, the developed LaCoO3/g-C3N4 electrode is a promising electrochemical platform for antipsychotic drugs and can be applied as an effective analytical device in quality control and routine quantification of the pharmaceutical industry.