纳米棒
表面改性
聚乙二醇
生物相容性
表面等离子共振
溴化物
肺表面活性物质
PEG比率
纳米技术
药物输送
材料科学
核化学
硝酸银
化学
化学工程
组合化学
色谱法
纳米颗粒
有机化学
生物化学
物理化学
财务
工程类
经济
作者
Shunping Han,Khuloud T. Al‐Jamal
标识
DOI:10.1002/ppsc.202300043
摘要
Abstract Synthesizing gold nanorods (AuNRs) by seed‐mediated growth method results in the presence of undesired size and shape particles by‐products occupying 10–90% of the population. In this study, AuNRs are synthesized by the seed‐mediated growth method using cetyltrimethylammonium bromide (CTAB) as a surfactant. AuNRs with redshifted longitudinal localized surface plasmon resonance (LLSPR) peak, localized in the biological “transparency window” (650–1350 nm), are synthesized after optimizing seed solution, silver nitrate solution, and hydrochloric acid solution volumes, based on the published protocols. A two‐step purification method, dialysis followed by centrifugation, is applied to remove excess CTAB and collect LLSPR‐redshifted AuNRs with high rod purity (>90%). CTAB is subsequently exchanged with polyethylene glycol (PEG) to improve AuNRs biocompatibility. PEGylated AuNRs are confirmed innocuous to both SN4741 cells and B16F10 cells by the modified MTT assay and the modified lactate dehydrogenase (LDH) assay up to 1 n m and 24 h incubation. In this study, a combined facile synthesis, purification, and surface functionalization approach is proposed to obtain water‐dispersible monodispersed AuNRs for drug delivery applications.
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