Effect of arsenic poisoning on antioxidative enzymes in the experimental guinea pigs

Arsenicosis is a global health problem affecting many millions of people and animals. In the present study Arsenic toxicity was induced in Guinea pigs by feeding 1% aqueous solution of Arsenic trioxide @ 10mg/kg and 1mg/kg to produce acute and chronic toxicity, respectively. The estimation of antioxidative enzymes in the liver samples was carried out to evaluate the release of free radicals due to Arsenic toxicity which caused significant increase in the production of Superoxide Dismutase in early phase of toxicity and Catalase in later phase of toxicity.