Identification of a Role for the Tyrosine Kinase JAK2 in Both Skeletal Muscle Mitogenesis and Myogenesis

This study was conducted to investigate what roles JAK2 might play in skeletal myoblast proliferation and terminal differentiation.These results represent the first characterization of the requirement of JAK2 in skeletal muscle proliferation, and suggest a novel role, potentially independent of kinase activity, for JAK2 in skeletal muscle myogenesis.