Light Promotes Neural Correlates of Fear Memory via Enhancing Brain-Derived Neurotrophic Factor (BDNF) Expression in the Prelimbic Cortex

Exposure to light has been shown to enhance vigilance and improve working memory, possibly due to changes in prefrontal function. Ample evidence supports the critical role of prefrontal cortex (PFC) in fear memory performance. However, the effects of light on memory processing and its potential mechanisms remain unclear. Here, through rats exposure conditioned to light at different memory phases, we sought evidence for the influences by employing behavioral tests, pharmacological infusions, immunoblotting, and electrophysiological recording. Exposure to light immediately following conditioning of 30 min or longer could effectively improve consolidation of fear memory without altering short-term memory or upgrading the original fear. The absence of significant freezing during baseline and intertrial interval periods ruled out the possibility of a general induction of freezing by light. Meanwhile, rats exposed to light in homecages or conditioning chambers exhibited a similar memory phenotype, indicating that light specifically enhanced the fear stimulus rather than the contextual environment. Furthermore, light exposure elevated the training-induced brain-derived neurotrophic factor (BDNF) expression in the prelimbic, but not infralimbic, subregion of the PFC. Moreover, the BDNF-TrkB pathway, but not the BDNF-p75NTR pathway, was involved in light-mediated fear memory. The enhancement in BDNF activity effectively facilitated firing correlates of prelimbic pyramidal neurons but not fast-spiking interneurons. Blocking the training-induced BDNF by its antibody abolished the effects of light on neural function and fear memory. Therefore, our findings indicate that light enhances training-induced BDNF expression that promotes the neural correlate of memory function.