生物
肠道菌群
免疫系统
胃肠道
骨重建
平衡
免疫学
肠-脑轴
失调
微生物学
内分泌学
生物化学
作者
Ye Tu,Ran Yang,Xin Xu,Xuedong Zhou
标识
DOI:10.1002/jlb.3mr0321-755r
摘要
Abstract The gastrointestinal tract is colonized by trillions of microorganisms, consisting of bacteria, fungi, and viruses, known as the “second gene pool” of the human body. In recent years, the microbiota-gut-bone axis has attracted increasing attention in the field of skeletal health/disorders. The involvement of gut microbial dysbiosis in multiple bone disorders has been recognized. The gut microbiota regulates skeletal homeostasis through its effects on host metabolism, immune function, and hormonal secretion. Owing to the essential role of the gut microbiota in skeletal homeostasis, novel gut microbiota-targeting therapeutics, such as probiotics and prebiotics, have been proven effective in preventing bone loss. However, more well-controlled clinical trials are still needed to evaluate the long-term efficacy and safety of these ecologic modulators in the treatment of bone disorders.
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