胍丁胺
中枢神经系统
祖细胞
神经科学
神经干细胞
神经细胞
医学
神经系统
细胞
生物
干细胞
细胞生物学
遗传学
氨基酸
精氨酸
作者
Renée Kosonen,Sumit Barua,Jong Min Kim,Jong-Ho Lee
出处
期刊:Anatomy & Cell Biology
[Korean Association of Anatomists]
日期:2021-06-30
卷期号:54 (2): 143-151
被引量:2
摘要
Agmatine, the primary decarboxylation product of L-arginine, generated from arginine decarboxylase. Since the discovery of agmatine in the mammalian brain in the 1990s, an increasing number of agmatine-mediated effects have been discovered, demonstrating the benefits of agmatine on ischemic strokes, traumatic brain injury and numerous psychological disorders such as depression, anxiety, and stress. Agmatine also has cellular protective effects and contributes to cell proliferation and differentiation in the central nervous system (CNS). Neural progenitor cells are an important component in the recovery and repair of many neurological disorders due to their ability to differentiate into functional adult neurons. Recent data has revealed that agmatine can regulate and increase proliferation and the fate of progenitor cells in the adult hippocampus. This review aims to summarise and discuss the role of agmatine in the CNS; specifically, the effects and relationship between agmatine and neural progenitor cells and how these ideas can be applied to potential therapeutic application.
科研通智能强力驱动
Strongly Powered by AbleSci AI