Effect of Sugammadex During Transcranial Electrical Motor Evoked Potentials Monitoring in Spinal Surgery: A Randomized Controlled Trial

苏伽马德克斯 罗库溴铵 医学 四分位间距 麻醉 神经肌肉阻滞 神经肌肉监测 外科 插管
作者
Haiyang Liu,Minyu Jian,Chengwei Wang,Lanyi Nie,Fa Liang,Kuo Liu,Kaiying Zhang,Hui Qiao,Ruquan Han
出处
期刊:Journal of Neurosurgical Anesthesiology [Lippincott Williams & Wilkins]
卷期号:35 (2): 224-231 被引量:4
标识
DOI:10.1097/ana.0000000000000820
摘要

Introduction: Neuromuscular blockade suppresses transcranial electrical motor evoked potential (TceMEP) amplitude and is usually avoided during TceMEP monitoring. In this randomized controlled trial, we investigated whether rocuronium-induced suppression of TceMEP amplitude could be reversed by sugammadex in patients undergoing spine surgery. Methods: Seventy-six patients undergoing spinal surgery were randomly allocated into sugammadex and control groups. In the sugammadex group, a rocuronium infusion was titrated to maintain moderate neuromuscular blockade (2 twitches on train-of-four) until dural opening when the rocuronium infusion was discontinued and 2 mg/kg sugammadex administered. In the control group, no neuromuscular blockade was administered after induction of anesthesia. The primary outcome was a comparison between sugammadex and control groups of mean TceMEP amplitudes in the abductor pollicis brevis muscles of both upper extremities 5 minutes after dural. Secondary outcomes included TceMEP amplitudes at 10, 20, 30, and 60 minutes after dural opening. Results: Sixty-six patients were included in the analysis. TceMEP amplitudes were significantly greater in the sugammadex group (629 μV, interquartile range: 987 μV) than in the control group (502 μV, interquartile range: 577 μV; P =0.033) at 5 minutes after dural opening. TceMEP amplitudes were also greater in the sugammadex group at 10 minutes ( P =0.0010), 20 minutes ( P =0.003), 30 minutes ( P =0.001), and 60 minutes ( P =0.003) after dural opening. Conclusions: Moderate neuromuscular blockade induced by continuous infusion of rocuronium was effectively reversed by sugammadex. This suggests that sugammadex could be used to enhance TceMEP waveform monitoring during spine surgery requiring muscle relaxation.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
2秒前
CodeCraft应助gemini0615采纳,获得30
3秒前
6秒前
小白完成签到 ,获得积分10
6秒前
易吴鱼完成签到 ,获得积分10
6秒前
看火人完成签到 ,获得积分10
6秒前
铅笔完成签到,获得积分10
7秒前
狂野元枫完成签到 ,获得积分10
10秒前
搜集达人应助111采纳,获得10
10秒前
10秒前
Zoe完成签到,获得积分10
10秒前
Wtony发布了新的文献求助10
12秒前
简简单单完成签到 ,获得积分10
12秒前
研友_2484完成签到,获得积分10
13秒前
14秒前
Vxfhfdhkcds发布了新的文献求助10
17秒前
lu完成签到,获得积分10
18秒前
倔强的大萝卜完成签到 ,获得积分0
20秒前
20秒前
21秒前
冷艳的纸鹤完成签到,获得积分10
21秒前
Christine完成签到,获得积分10
22秒前
星辰大海应助chenhua5460采纳,获得10
23秒前
23秒前
gemini0615发布了新的文献求助30
24秒前
小宋发布了新的文献求助10
25秒前
冷酷蛋挞发布了新的文献求助10
28秒前
Jasper应助gemini0615采纳,获得10
30秒前
科研通AI5应助吾问无为谓采纳,获得10
31秒前
努力游游完成签到,获得积分10
31秒前
Vxfhfdhkcds完成签到 ,获得积分10
32秒前
烟花应助忧心的映真采纳,获得10
32秒前
32秒前
33秒前
醉熏的红酒完成签到,获得积分10
33秒前
winner2030完成签到 ,获得积分20
33秒前
知墨完成签到 ,获得积分10
34秒前
达达尼发布了新的文献求助10
35秒前
37秒前
逸兴遄飞发布了新的文献求助10
37秒前
高分求助中
【此为提示信息,请勿应助】请按要求发布求助,避免被关 20000
Technologies supporting mass customization of apparel: A pilot project 450
Mixing the elements of mass customisation 360
Периодизация спортивной тренировки. Общая теория и её практическое применение 310
the MD Anderson Surgical Oncology Manual, Seventh Edition 300
Nucleophilic substitution in azasydnone-modified dinitroanisoles 300
Political Ideologies Their Origins and Impact 13th Edition 260
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 物理 生物化学 纳米技术 计算机科学 化学工程 内科学 复合材料 物理化学 电极 遗传学 量子力学 基因 冶金 催化作用
热门帖子
关注 科研通微信公众号,转发送积分 3781113
求助须知:如何正确求助?哪些是违规求助? 3326545
关于积分的说明 10227650
捐赠科研通 3041675
什么是DOI,文献DOI怎么找? 1669552
邀请新用户注册赠送积分活动 799100
科研通“疑难数据库(出版商)”最低求助积分说明 758734