Alternative synthetic approaches for nucleotides and derivatives

We have focused our attention on alternative synthetic approaches for nucleotides and dinucleotides, that simplifies purification and/or improves sustainability. On one hand, we developed a liquid-phase synthesis using a benzene-centred tripodal support to prepare adenine nucleoside phosphoesters and methylenebisphosphonate derivatives. On the other hand, we used mechanochemistry, a technique that enables solid/solid reactions through mechanical grinding under solventless or solvent-free conditions, to get access to dinucleotides.