Arylative Cyclization of Indole-1-carboxamides with 1,6-Enynes for the Synthesis of Polycyclic Indole Scaffolds

A new alkyne annulation strategy has been developed for the synthesis of polycyclic indole derivatives through a cascade of C–H annulation and Michael addition reactions. This is the first report on sequential alkyne annulation and aza‐Michael addition reactions of indole‐1‐carboxamides with alkyne tethered substrates.