巨噬细胞
脂肪组织
非酒精性脂肪肝
免疫系统
表型
先天免疫系统
疾病
生物
胰岛素抵抗
免疫学
医学
脂肪肝
生物信息学
糖尿病
病理
内分泌学
体外
生物化学
基因
作者
Kristin R. Peterson,Matthew A. Cottam,Arion Kennedy,Alyssa H. Hasty
标识
DOI:10.1016/j.tips.2018.03.001
摘要
Macrophages are cells of the innate immune system that are resident in all tissues, including metabolic organs such as the liver and adipose tissue (AT). Because of their phenotypic flexibility, they play beneficial roles in tissue homeostasis, but they also contribute to the progression of metabolic disease. Thus, they are ideal therapeutic targets for diseases such as insulin resistance (IR), nonalcoholic fatty liver disease (NAFLD), and atherosclerosis. Recently, discoveries in the area of drug delivery have facilitated phenotype-specific targeting of macrophages. In this review we discuss advances in potential therapeutics for metabolic diseases via macrophage-specific delivery. We highlight micro- and nanoparticles, liposomes, and oligopeptide complexes, and how they can be used to alter macrophage phenotype for a more metabolically favorable tissue environment.
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