生物
浆细胞样树突状细胞
免疫学
先天免疫系统
干扰素
免疫系统
树突状细胞
获得性免疫系统
造血
Ⅰ型干扰素
TLR9型
髓样
细胞生物学
干细胞
DNA甲基化
基因表达
基因
生物化学
标识
DOI:10.1146/annurev.immunol.23.021704.115633
摘要
▪ Abstract Type 1 interferon-(α, β, ω)-producing cells (IPCs), also known as plasmacytoid dendritic cell precursors (pDCs), represent 0.2%–0.8% of peripheral blood mononuclear cells in both humans and mice. IPCs display plasma cell morphology, selectively express Toll-like receptor (TLR)-7 and TLR9, and are specialized in rapidly secreting massive amounts of type 1 interferon following viral stimulation. IPCs can promote the function of natural killer cells, B cells, T cells, and myeloid DCs through type 1 interferons during an antiviral immune response. At a later stage of viral infection, IPCs differentiate into a unique type of mature dendritic cell, which directly regulates the function of T cells and thus links innate and adaptive immune responses. After more than two decades of effort by researchers, IPCs finally claim their place in the hematopoietic chart as the most important cell type in antiviral innate immunity. Understanding IPC biology holds future promise for developing cures for infectious diseases, cancer, and autoimmune diseases.
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