内科学
内分泌学
MAPK/ERK通路
磷酸化
阉割
体内
生物
梨状皮质
激酶
蛋白激酶A
激素
中枢神经系统
医学
细胞生物学
生物技术
作者
Katalin Barabás,Éva M. Szegő,Attila Kaszás,G Nagy,Gábor Juhász,István M. Ábrahám
标识
DOI:10.1111/j.1365-2826.2006.01447.x
摘要
In addition to the classical direct genomic mechanisms of action, oestrogen also exerts poorly understood, nonclassical effects on the signalling system in neurones. In the present study, we investigated whether sex differences exist in gonadectomy‐ and oestrogen‐induced effects on p44/42 mitogen‐activated protein kinase (MAPK) phosphorylation in specific brain regions of mice. We demonstrate that MAPK immunoreactivity was not altered by gonadectomy or oestrogen treatment in either sex. However, we show that the level of phosphorylated MAPK (pMAPK) within the anteroventral periventricular nucleus (AVPV) was consistently higher in males than females irrespective of gonadal steroid hormone status. In addition, gonadectomy was found to decrease pMAPK immunoreactivity within the piriform cortex of males. Oestrogen increased pMAPK immunoreactivity in the medial preoptic area and AVPV of females, but failed to have the same effect in male mice. Overall, these results demonstrate a marked sex difference in oestrogen‐induced alteration of MAPK phosphorylation in the brain in vivo .
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