黄斑变性
萎缩
脉络膜新生血管
视网膜色素上皮
视网膜
医学
生物
内科学
眼科
作者
Zhenglin Yang,Charity A. Stratton,Peter J. Francis,Mark E. Kleinman,Perciliz L. Tan,Daniel Gibbs,Zongzhong Tong,Haoyu Chen,Ryan Constantine,Xian Yang,Yuhong Chen,Jiexi Zeng,Lisa Davey,Xiang Ma,Vincent Hau,Chi Wang,Jennifer N. Harmon,Jeanette Buehler,Erik Pearson,Shrena Patel
标识
DOI：10.1056/nejmoa0802437
摘要
The TLR3 412Phe variant confers protection against geographic atrophy, probably by suppressing the death of retinal pigment epithelial cells. Since double-stranded RNA (dsRNA) can activate TLR3-mediated apoptosis, our results suggest a role of viral dsRNA in the development of geographic atrophy and point to the potential toxic effects of short-interfering-RNA therapies in the eye.
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