Recent Developments in Gastrointestinal Absorption and Tissue Utilization of Peptides: A Review

Considerable evidence has been accumulated regarding the absorption of dipeptides and tripeptides, yet, even with the growing body of knowledge, the nutritional and metabolic significance of peptide absorption is not fully understood, especially in ruminants. Muscle, mammary gland, liver, kidney, intestinal mucosa, and other tissues either have been shown to have, or are suspected to have, the ability to utilize peptides as a source of AA to meet cellular demands. Investigations suggest that ruminal microbes have the ability to produce substantial amounts of small peptides as a consequence of their hydrolysis of dietary proteins. The extent to which intact peptides may be absorbed into the blood is controversial. Some of the inconsistency in reported observations may be because of limitations of analytical procedures, species differences, or both. Peptide absorption appears to be an important physiological process in ruminants and may constitute the primary source of absorbed AA. The recent observation that the stomach region of the gastrointestinal tract may be an important site of peptide absorption is highly significant. Emerging evidence for the contribution that peptide absorption makes to AA provisioning of ruminants may change some of the currently held views about protein utilization in these unique animals.