医学
纤维化
字体
肝损伤
病理
内科学
计算机科学
操作系统
作者
Jung-Chou Chen,Chi‐Cheng Tsai,Leih-Der Chen,Hing-Ho Chen,Wen-Chuang Wang
标识
DOI:10.1142/s0192415x00000222
摘要
Gypenoside is a saponins extract derived from the Gynostemma pentaphyllum. The purpose of this study was to evaluate the hepatoprotective and antifibrotic potential of Gypenoside on chronic liver injury induced by CCl 4 for 8 wks. The results indicated that the increase of SGOT, SGPT activities in CCl 4 liver injury were significantly reduced by treatment with Gypenoside. It also elevated the A/G ratio. For the study of anti-fibrotic potential, Gypenoside reduced the collagen content by 33%. These phenomena were confirmed by pathologic observation; thinner bands of liver collagen were found. The results suggest that Gypenoside has hepatoprotective and anti-fibrotic activities.
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