光热治疗
材料科学
盐酸阿霉素
癌症
纳米技术
纳米颗粒
体内
介孔二氧化硅
阿霉素
放射治疗
生物医学工程
化疗
医学
介孔材料
内科学
放射科
化学
催化作用
生物技术
外科
生物
生物化学
作者
Qing Bao,Ying Zhang,Xiangyu Liu,Tao Yang,Y. H. Hui,Mingying Yang,Chuanbin Mao
标识
DOI:10.1002/adom.202201482
摘要
Abstract Due to the complexity and heterogeneity of cancer, the clear and accurate tumor imaging and image‐guided multimodal synergistic therapy are highly in demand. Here, bismuth (Bi)‐based mesoporous‐silica‐coated nanoparticles (BMSNs) are successfully fabricated with the silica shell thickness being lower than the Bi nanoparticle diameter. Then, an MCF‐7 breast cancer‐targeting peptide (termed AR) is modified onto the surface of BMSNs. The obtained nanoparticles (BMSN‐AR) show a significantly higher loading of doxorubicin hydrochloride (DOX). The resultant BMSN‐AR‐DOX can agglomerate in the tumor site, enabling enhanced computed tomography (CT) imaging of the whole tumor. Under 808 nm near‐infrared (NIR) laser irradiation, the BMSN‐AR‐DOX also effectively converts light energy into thermal energy to achieve synergistic chemo‐photothermal therapy in vivo. The chemo‐photothermal combination therapy is found to be more effective than chemotherapy or photothermal therapy alone. This work demonstrates that tumor‐homing peptides can guide nanoparticles to tumors and allow the nanoparticles to enhance cancer imaging and photothermal/chemo combination therapy.
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