Nuciferine inhibits pressure overload-induced cardiac remodeling by activating the SENP1-ACSL4-ferroptosis axis

This study is the first to clarify that NF inhibits cardiomyocyte ferroptosis via the SENP1-ACSL4 axis to generate cardiovascular beneficial effects. More significantly, our work demonstrated that NF is an effective medicine with clinical translational promise, and that targeting ACSL4 and SENP1 can provide novel therapies for patients with cardiac remodeling and heart failure.