Stimuli-responsive nanozymes for wound healing: From design strategies to therapeutic advances

Nanozymes, which mimic the activity of natural enzymes, have demonstrated significant advantages in wound healing. Stimuli-responsive nanozymes, a novel design type developed recently, are capable of on-demand targeted release, catalytic activity modulation, and facilitating synergistic therapeutic strategies. Such advancements further enhance the safety and efficacy of nanozyme-based treatments. Although numerous studies have reported their high efficiency in promoting wound healing, there remains a lack of updated review literature on this topic. This paper starts by exploring the design strategies of advanced stimuli-responsive nanozymes (including types responsive to pH, glucose, enzyme, light, ultrasound, and magnetic fields), providing a comprehensive analysis of their underlying mechanisms, while highlighting their application progress across diverse wound types. Furthermore, this paper provides a forward-looking perspective on the future development of stimuli-responsive nanozymes.