四唑
化学
抽搐的
药理学
体内
医学
立体化学
受体
生物化学
生物
生物技术
作者
Shivangi Jaiswal,Kanika Verma,Jaya Dwivedi,Swapnil Sharma
标识
DOI:10.1016/j.ejmech.2024.116388
摘要
Neurological disorders are the leading cause of a large number of mortalities and morbidities. Nitrogen heterocyclic compounds have been pivotal in exhibiting wide array of therapeutic applications. Among them, tetrazole is a ubiquitous class of organic heterocyclic compounds that have attracted much attention because of its unique structural and chemical properties, and a wide range of pharmacological activities comprising anti-convulsant effect, antibiotic, anti-allergic, anti-hypertensive to name a few. Owing to significant chemical and biological properties, the present review aimed at highlighting the recent advances in tetrazole derivatives with special emphasis on their role in the management of neurological diseases. Besides, in-depth structure-activity relationships, molecular docking studies, and associated modes of action of tetrazole derivatives evident in in vitro, in vivo preclinical, and clinical studies have been discussed.
科研通智能强力驱动
Strongly Powered by AbleSci AI