材料科学
制作
纳米技术
药物输送
自愈水凝胶
透皮
聚乙二醇
生物医学工程
化学工程
高分子化学
医学
替代医学
病理
药理学
工程类
作者
Delaram Ghanbariamin,Mohamadmahdi Samandari,Pejman Ghelich,Sina Shahbazmohamadi,Tannin A. Schmidt,Yupeng Chen,Ali Tamayol
出处
期刊:Small
[Wiley]
日期:2023-04-07
卷期号:19 (29)
被引量:7
标识
DOI:10.1002/smll.202207131
摘要
Abstract Microneedles have recently emerged as a powerful tool for minimally invasive drug delivery and body fluid sampling. To date, high‐resolution fabrication of microneedle arrays (MNAs) is mostly achieved by the utilization of sophisticated facilities and expertise. Particularly, hollow microneedles have usually been manufactured in cleanrooms out of silicon, resin, or metallic materials. Such strategies do not support the fabrication of microneedles from biocompatible/biodegradable materials and limit the capability of multimodal drug delivery for the controlled release of different therapeutics through a combination of injection and sustained diffusion. This study implements low‐cost 3D printers to fabricate relatively large needle arrays, followed by repeatable shrink‐molding of hydrogels to form high‐resolution molds for solid and hollow MNAs with controllable sizes. The developed strategy further enables modulating surface topography of MNAs to tailor their surface area and instantaneous wettability for controllable drug delivery and body fluid sampling. Hybrid gelatin methacryloyl (GelMA)/polyethylene glycol diacrylate (PEGDA) MNAs are fabricated using the developed strategy that can easily penetrate the skin and enable multimodal drug delivery. The proposed method holds promise for affordable, controllable, and scalable fabrication of MNAs by researchers and clinicians for controlled spatiotemporal administration of therapeutics and sample collection.
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