麦角甾醇
化学
缺血
再灌注损伤
药理学
肝移植
缺氧(环境)
移植
生物化学
医学
内科学
有机化学
氧气
作者
Hong Hu,Yanhui Li,Zhengyi Shi,Xiangli Zhao,Xueqi Lan,Meng Wu,Bo Tang,Yeting Zhang,Xinye Huang,Pengfei Bu,Yi Guo,Xiaosheng Tan,Changxing Qi,Yonghui Zhang
标识
DOI:10.1016/j.bioorg.2023.106530
摘要
Hepatic ischemia/reperfusion injury is a major cause of hypohepatia after surgical procedures such as hypovolemic shock, transplantation, and so on. In our continuous study of bioactive natural products from fungus, eight ergosterol-type sterides (1–8), including two undescribed compounds, sterolaspers A (1) and B (2), were isolated from Aspergillus sp. TJ507. Structure elucidation was accomplished by extensive spectroscopic analysis and comparison with the reported NMR data as well as X-Ray single crystal diffraction tests. Activity screen of these isolates showed 5α-stigmast-3,6-dione (3) possessing anti-hypoxia injury effects against CoCl2-induced hypoxia damage in hepatocytes. More importantly, compound 3 could improve liver function, alleviate liver damage, and restrain the hepatocellular apoptosis in hepatic ischemia/reperfusion injury murine model. As such, this ergosterol-type steride, 5α-stigmast-3,6-dione (3), might serve as lead structure for the development of novel hepatoprotective agents in the clinical treatment of hepatic ischemia/reperfusion injury.
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