氧化应激
超氧化物歧化酶
活性氧
神经保护
药理学
过氧化氢酶
谷胱甘肽过氧化物酶
抗氧化剂
生物相容性材料
铌
化学
医学
生物化学
生物医学工程
有机化学
作者
Heng Yang,Lili Xia,Xuanxuan Ye,Jiayi Xu,Tianfeng Liu,Linping Wang,Shuai Zhang,Wei Feng,Dongshu Du,Yu Chen
标识
DOI:10.1002/anie.202303539
摘要
Abstract Hypertension, as a leading risk factor for cardiovascular diseases, is associated with oxidative stress and impairment of endogenous antioxidant mechanisms, but there is still a tremendous knowledge gap between hypertension treatment and nanomedicines. Herein, we report a specific nanozyme based on ultrathin two‐dimensional (2D) niobium carbide (Nb 2 C) MXene, termed Nb 2 C MXenzyme, to fight against hypertension by achieving highly efficient reactive oxygen species elimination and inflammatory factors inhibition. The biocompatible Nb 2 C MXenzyme displays multiple enzyme‐mimicking activities, involving superoxide dismutase, catalase, glutathione peroxidase, and peroxidase, inducing cytoprotective effects by resisting oxidative stress, thereby alleviating inflammatory response and reducing blood pressure, which is systematically demonstrated in a stress‐induced hypertension rat model. This strategy not only opens new opportunities for nanozymes to treat hypertension but also expands the potential biomedical applications of 2D MXene nanosystems.
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