光动力疗法
材料科学
介孔材料
纳米技术
纳米材料
合理设计
聚合物
介孔二氧化硅
催化作用
有机化学
化学
复合材料
作者
Hongyu Li,Han Xu,Guanglin Wang,Junchang Chen,Dandan Ji,Yangyang Huang,Guoqing Cui,Hui He,Zhengqing Guo
标识
DOI:10.1021/acsami.2c22095
摘要
Effective clinical practice of precise photodynamic therapy (PDT) is severely impeded by the inherent drawbacks and aggregation propensity of conventional photosensitizers. An all-in-one approach is highly desired to optimize structural features, photophysical properties, and pharmacokinetic behaviors of photosensitizers. Herein, we have fabricated mesoporous boron dipyrromethene-bridged coordination polymer nanophotosensitizers (BCP-NPs) for high-performance PDT via a unique solvent-assisted assembly strategy. Distinctive photophysical and structural characteristics of BCP-NPs confer enhanced photodynamic activities, together with high cellular uptake and ultrahigh stability. Moreover, BCP-NPs showed excellent tumor accumulation and prolonged tumor retention, achieving eradication of the triple-negative breast cancer (TNBC) model under low-power-density LED irradiation. This work has provided a valuable paradigm for the construction of mesoporous photoactive nanomaterials for biophotonic applications.
科研通智能强力驱动
Strongly Powered by AbleSci AI