Multi-site-specific polymer grafting from nucleic acids

The site-controlled grafting of multiple polymers from nucleic acids and their purification remain challenging. In this issue of Chem, Matyjaszewski, Das, and co-workers develop a universal phosphoramidite reagent containing an atom-transfer radical polymerization (ATRP) initiator that paves the way to expanding the architectural space of well-defined nucleic-acid-polymer hybrids (NAPHs). The site-controlled grafting of multiple polymers from nucleic acids and their purification remain challenging. In this issue of Chem, Matyjaszewski, Das, and co-workers develop a universal phosphoramidite reagent containing an atom-transfer radical polymerization (ATRP) initiator that paves the way to expanding the architectural space of well-defined nucleic-acid-polymer hybrids (NAPHs). Expanding the architectural horizon of nucleic-acid-polymer biohybrids by site-controlled incorporation of ATRP initiators in DNA and RNAJeong et al.ChemAugust 22, 2023In BriefMatyjaszewski, Das, and co-workers have synthesized and incorporated SBiB, a serinol-based ATRP-initiator-functionalized phosphoramidite, into nucleic acids during solid-phase synthesis in a site-controlled manner. They demonstrate that polymers can be grown from one or multiple SBiB residues integrated into nucleic acids with a narrow molecular-weight distribution. This method expands the architectural scope of nucleic-acid-polymer hybrids beyond simple diblock copolymers. Full-Text PDF