程序性细胞死亡
铜
冲程(发动机)
病态的
缺血
平衡
机制(生物学)
医学
神经科学
再灌注损伤
细胞
病理生理学
中枢神经系统
生物信息学
生物
化学
细胞凋亡
病理
内科学
生物化学
机械工程
哲学
认识论
工程类
有机化学
作者
Gang‐Ding Peng,Yongpan Huang,Guangdi Xie,Jiayu Tang
标识
DOI:10.3389/fphar.2024.1409317
摘要
Copper is an important mineral, and moderate copper is required to maintain physiological processes in nervous system including cerebral ischemia/reperfusion (I/R) injury. Over the past few decades, copper induced cell death, named cuprotosis, has attracted increasing attention. Several lines of evidence have confirmed cuprotosis exerts pivotal role in diverse of pathological processes, such as cancer, neurodegenerative diseases, and I/R injury. Therefore, an in-depth understanding of the interaction mechanism between copper-mediated cell death and I/R injury may reveal the significant alterations about cellular copper-mediated homeostasis in physiological and pathophysiological conditions, as well as therapeutic strategies deciphering copper-induced cell death in cerebral I/R injury.
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