Reactive oxygen/nitrogen species scavenging multi-enzyme mimetic ultrasmall calcium hexacyanoferrate (Ⅲ) nanozyme for hypertension remedy

Oxidative stress in the rostral ventrolateral medulla plays a pivotal role in the pathogenesis and progression of neurogenic hypertension, but limited strategy is currently available to maintain blood pressure and improve the life quality of patients with hypertension. The development of biocompatible nanomaterials with intrinsic antioxidative enzyme-mimicking activities is a promising approach to treat hypertension. Herein, we develop an ultrasmall calcium hexacyanoferrate (Ⅲ) nanoparticles (CaHF NPs) with the robust broad-spectrum reactive oxygen/nitrogen species (RONS) scavenging and anti-inflammation abilities for the treatment of hypertension. Specifically, CaHF NPs are simultaneously featured with superoxide dismutase-, peroxidase-, glutathione peroxidase- and catalase-like activities, protecting cell from oxidative stress-induced damage. Importantly, CaHF NPs alleviate hypertension through restoring endogenous redox homeostasis and reducing the secretion of proinflammatory cytokines. Our work not only provides a feasible therapeutic method for remedying hypertension, but also expands the biomedical applications of nanomaterials in treating oxidative stress-related central nervous system diseases.