透明质酸
厚朴酚
肝细胞癌
阿霉素
化学
硫酸化
纳米颗粒
药理学
癌症研究
医学
化疗
内科学
生物化学
纳米技术
材料科学
解剖
作者
Qiyang Zhou,Jingliang Wu,Bo Lian,Bo Zhang,Pingping Zhang,Ruiyan Pan
出处
期刊:ACS applied nano materials
[American Chemical Society]
日期:2022-10-07
卷期号:5 (10): 15070-15082
被引量:1
标识
DOI:10.1021/acsanm.2c03245
摘要
Cancer-associated fibroblasts (CAFs) play a crucial role in the progress of tumor growth, metastasis, and multidrug resistance. In this study, glycyrrhetinic acid-modified sulfated hyaluronic acid nanoparticles (MDHG) were prepared for the codelivery of doxorubicin (DOX) and magnolol (MAG). To mimic the tumor microenvironment (TME), we successfully established tumor cells/CAFs mixed research models in vivo and in vitro. The results showed that MDHG could be taken up by both CAFs and tumor cells and exhibited strong antiproliferation and antimigration effects in the mixed cell model in vitro. Moreover, the in vivo studies showed that MDHG effectively decreased the side effect of DOX and inhibited CAFs activation, tumor angiogenesis, antiproliferation, and lung metastasis on tumor cells, leading to enhanced antitumor effects. In summary, the study verified that there is a synergistic antitumor effect between DOX and MAG, and the combination therapy of DOX and MAG based on sulfated hyaluronic acid nanoparticles has potential in clinical application.
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