MST1 Kinase-Cx43-YAP/TAZ Pathway Mediates Disturbed Flow Endothelial Dysfunction

HomeCirculation ResearchVol. 131, No. 9MST1 Kinase-Cx43-YAP/TAZ Pathway Mediates Disturbed Flow Endothelial Dysfunction No AccessEditorialRequest AccessFull TextAboutView Full TextView PDFView EPUBSections ToolsAdd to favoritesDownload citationsTrack citationsPermissions ShareShare onFacebookTwitterLinked InMendeleyReddit Jump toNo AccessEditorialRequest AccessFull TextMST1 Kinase-Cx43-YAP/TAZ Pathway Mediates Disturbed Flow Endothelial Dysfunction Himanshu Meghwani and Bradford C. Berk Himanshu MeghwaniHimanshu Meghwani Department of Medicine, Aab Cardiovascular Research Institute (H.M.), University of Rochester School of Medicine and Dentistry, Rochester, NY. University of Rochester Neurorestoration Institute (H.M., B.C.B.), University of Rochester School of Medicine and Dentistry, Rochester, NY. Search for more papers by this author and Bradford C. BerkBradford C. Berk Correspondence to: Bradford C. Berk, MD, PhD, University of Rochester Neurorestoration Institute, University of Rochester School of Medicine and Dentistry, 601 Elmwood Ave, Box URNI Rochester, NY 14642. Email E-mail Address: [email protected] https://orcid.org/0000-0002-2767-4115 University of Rochester Neurorestoration Institute (H.M., B.C.B.), University of Rochester School of Medicine and Dentistry, Rochester, NY. Search for more papers by this author Originally published13 Oct 2022https://doi.org/10.1161/CIRCRESAHA.122.321921Circulation Research. 2022;131:765–767This article is a commentary on the followingMST1 Suppresses Disturbed Flow Induced AtherosclerosisFootnotesThe opinions expressed in this article are not necessarily those of the editors or of the American Heart Association.For Sources of Funding and Disclosures, see page 767.Correspondence to: Bradford C. Berk, MD, PhD, University of Rochester Neurorestoration Institute, University of Rochester School of Medicine and Dentistry, 601 Elmwood Ave, Box URNI Rochester, NY 14642. Email [email protected]rochester.eduReferences1. Humphrey JD, Schwartz MA. Vascular mechanobiology: homeostasis, adaptation, and disease.Annu Rev Biomed Eng. 2021; 23:1–27. doi: 10.1146/annurev-bioeng-092419-060810CrossrefMedlineGoogle Scholar2. Quan M, Lv H, Liu Z, Li K, Zhang C, Shi L, Yang X, Lei P, Zhu Y, Ai D. Mammalian sterile 20-like kinase 1 suppresses disturbed flow induced endothelial dysfunction and atherosclerosis.CircRes. 2022; 131:748–764. doi: 10.1161/CIRCRESAHA.122.321322LinkGoogle Scholar3. Wang K-C, Yeh Y-T, Nguyen P, Limqueco E, Lopez J, Thorossian S, Guan K-L, Li Y-SJ, Chien S. Flow-dependent YAP/TAZ activities regulate endothelial phenotypes and atherosclerosis.Proc Natl Acad Sci USA. 2016; 113:11525–11530. doi: 10.1073/pnas.1613121113.CrossrefMedlineGoogle Scholar4. 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Circulation Research. 2022;131:748-764 October 14, 2022Vol 131, Issue 9 Advertisement Article InformationMetrics © 2022 American Heart Association, Inc.https://doi.org/10.1161/CIRCRESAHA.122.321921PMID: 36252051 Originally publishedOctober 13, 2022 KeywordsEditorialsendothelial cellsgap junctionatherosclerosisconnexinPDF download Advertisement SubjectsAtherosclerosisEchocardiographyMagnetic Resonance Imaging (MRI)Nuclear Cardiology and PETTransplantation