New bioactive pyrrole alkaloid isolated from the Saudi Red Sea sponge Stylissa carteri with potential anticancer property against human lung adenocarcinoma cell line, and possible mechanisms

values at 24.08 µM, respectively. The new metabolite stylisinone caused strong cell cycle arrest at sub G1 and G2/M (22.43-fold and 2.28-fold, respectively), indicating its potential as an antitumor agent. Furthermore, stylisinone showed a marked increase in Annexin V-FITC necrotic cells (from 1.23 to 21.38%), making this molecule an attractive candidate for further mechanism of action studies.