Intergenerational Postoperative Neurocognitive Disorder in a Rat Model: Initiating Mechanisms and Pharmacological Prevention

These findings suggest a role for hypothalamic NKCC1/γ-aminobutyric acid type A receptor/AVP signaling in sevoflurane-triggered PND in adult male rats, which also affects their future sevoflurane-unexposed offspring. NKCC1 and glucocorticoid receptors could serve as therapeutic targets for prevention of sevoflurane-induced PND in exposed rats and in their future offspring.