Dexmedetomidine Regulates HMGB1 Transferred by HK-2 Cell-Derived Exosomes to Suppress Myocardial Cell Pyroptosis by Activating the TLR4 Signaling Pathway.

Dex can significantly inhibit the expression of HMGB1 in HK-2 cell-derived exosomes exposed to H/R and inhibit AC16 cell pyroptosis through exosome uptake and the effect of HMGB1 on the TLR4 signaling pathway.