部分
生物污染
伤口敷料
化学
伤口护理
止血剂
伤口愈合
抗菌活性
广谱
组合化学
止血
细菌
医学
有机化学
外科
材料科学
生物化学
生物
膜
复合材料
遗传学
作者
Yidan Zhang,Buket Demir,Gregory Bertsch,Mingyu Qiao
标识
DOI:10.1016/j.ijbiomac.2022.123121
摘要
With emerging needs of wound care management, a multi-functional wound dressing is needed. To prevent infection and reduce patient suffering, antibacterial efficacy against a broad-spectrum of bacteria plus robust antifouling are among the most preferred properties. In this study, a wound dressing was created with antibacterial and anti-fouling capabilities is presented. The approaches used a synthesized tri-functional copolymer comprised of an N-halamine precursor moiety, a marine-inspired surface binding dopamine moiety, and a zwitterionic anti-adhesion moiety bonded onto a commercial cotton gauze. The resulting HaloCare™ wound dressing demonstrated >99.99 % inactivation within 5 min against E. coli and a panel of ESKAPE pathogens plus achieved 98.77 % reduction of non-specific protein binding. HaloCare was also shown to be compatible with hemostatic agents without impacting hemostatic efficacy. HaloCare shows great potential particularly in traumatic injury events as an infection preventing and hemostatic wound management system.
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