电泳剂
氨基酸
天冬氨酸
功能(生物学)
蛋白质功能
化学
氨基酸残基
生物化学
组合化学
小分子
残留物(化学)
谷氨酸
计算生物学
生物
肽序列
催化作用
遗传学
基因
标识
DOI:10.1002/cmdc.202300623
摘要
Abstract It is of great importance to pinpoint specific residues or sites of a protein in biological contexts to enable desired mechanism of action for small molecules or to precisely control protein function. In this regard, acidic residues including aspartic acid (Asp) and glutamic acid (Glu) hold great potential due to their great prevalence and unique function. To unlock the largely untapped potential, great efforts have been made recently by synthetic chemists, chemical biologists and pharmacologists. Herein, we would like to highlight the remarkable progress and particularly introduce the electrophiles that exhibit reactivity to carboxylic acids, the light‐induced reactivities to carboxylic acids and the genetically encoded noncanonical amino acids that allow protein manipulations at acidic residues. We also comment on certain unresolved challenges, hoping to draw more attention to this rapidly developing area.
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