生物
基因组
谱系(遗传)
系统发育树
病毒学
遗传学
基因
系统发育学
进化生物学
病毒
克莱德
序列分析
DNA测序
基因组组织
作者
Ludmila Karen dos Santos Silva,Rodrigo Araújo Lima Rodrigues,Ana Cláudia dos Santos Pereira Andrade,Hiroyuki Hikida,Julien Andreani,Anthony Levasseur,Bernard La Scola,Jônatas Santos Abrahão
标识
DOI:10.1007/s00705-020-04542-5
摘要
Since its discovery, the first identified giant virus associated with amoebae, Acanthamoeba polyphaga mimivirus (APMV), has been rigorously studied to understand the structural and genomic complexity of this virus. In this work, we report the isolation and genomic characterization of a new mimivirus of lineage B, named moumouvirus. This new virus exhibits a structure and replicative cycle similar to those of other members of the family Mimiviridae. The genome of the new isolate is a linear double-strand DNA molecule of ~1.0 Mb, containing over 900 open reading frames. Genome annotation highlighted different translation system components encoded in the DNA of Borely moumouvirus, including aminoacyl-tRNA synthetases, translation factors, and tRNA molecules, in a distribution similar to that in other lineage B mimiviruses. Pan-genome analysis indicated an increase in the genetic arsenal of this group of viruses, showing that the family Mimiviridae is still expanding. Furthermore, phylogenetic analysis has shown that Borely moumouvirus is closely related to moumouvirus australiensis. This is the first mimivirus lineage B isolated from Brazilian territory to be characterized. Further prospecting studies are necessary for us to better understand the diversity of these viruses so a better classification system can be established.
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