Emerging role of m6A RNA methylation in nutritional physiology and metabolism

Summary N6‐methyladenine (m6A) is the most prevalent type of internal RNA methylation in eukaryotic mRNA and plays critical roles in regulating gene expression for fundamental cellular processes and diverse physiological functions. Recent evidence indicates that m6A methylation regulates physiology and metabolism, and m6A has been increasingly implicated in a variety of human diseases, including obesity, diabetes, metabolic syndrome and cancer. Conversely, nutrition and diet can modulate or reverse m6A methylation patterns on gene expression. In this review, we summarize the recent progress in the study of the m6A methylation mechanisms and highlight the crosstalk between m6A modification, nutritional physiology and metabolism.